ea0031p290 | Pituitary | SFEBES2013
Cabrera-Shaarp Victoria
, Richardson Stephanie
, Kowalski Alycia
, Antczak Doug
, Mukherjee Abir
, Mestre Amanda de
Objective: Chorionic gonadotrophin (CG) is a hormone induced during terminal differentiation of trophoblast cells that significantly influences pregnancy outcome. The TGFβ superfamily SMAD2/3 pathway regulates placental function but the activity of the alternative pathway through SMAD1/5/8 in the placenta is unknown. This study investigated the role of BMP4 signalling through SMAD1/5 in terminal differentiation of primary chorionic gonadotrophin-secreting trophoblast cell...